Phenanthrenes and derivatives
Apexbio Technology LLC CVT-313 199986-75-9 200mg
CVT-313 (CAS 199986-75-9) is a potent inhibitor of cyclin-dependent kinase 2 (CDK2) an enzyme essential for G1/S transition during cell cycle progression By targeting CDK2 CVT-313 effectively reduces hyperphosphorylation of retinoblastoma protein (Rb) leading to cell cycle arrest at the G1/S boundary In vitro studies with MRC-5 fibroblasts demonstrated significant growth inhibition Additionally CVT-313 induces apoptosis in diffuse large B-cell lymphoma by diminishing phosphorylation of Rb at T821 and downregulating anti-apoptotic protein Mcl-1 In animal models of arterial restenosis CVT-313 significantly reduces neointimal proliferation indicating potential utility for proliferative disorders research
Medchemexpress LLC Ivabradine hydrochloride | 148849-67-6 | 99.71% | 200 MG
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). It reduces heart rate in a dose-dependent manner without affecting blood pressure.
- Potent and orally active HCN channel blocker.
- Inhibits cardiac pacemaker current (If).
- Reduces heart rate dose-dependently without modifying blood pressure.
- Exhibits anticonvulsant, anti-ischaemic, and anti-anginal activity.
- Attenuates PTZ- and PICRO-induced seizures.
- Exhibits antioxidant effects in brain areas.
- Reduces cleaved caspase-3 expression.
Apexbio Technology LLC CHELIDAMIC-ACID-200MG
Chelidamic acid (CAS No 138-60-3) is a compound explored within the biomedical research category for its potential therapeutic applications Originating from studies focused on derivative analogs of known bioactive molecules it primarily targets enzymatic pathways involved in inflammatory and oxidative processes Its mechanism of action involves modulating key biochemical pathways which could influence cellular responses to stress and damage Demonstrating in vitro activity generally in the nanomolar to low micromolar range Chelidamic acid is frequently utilized in cell models and animal studies to assess its efficacy and safety profile These evaluations are critical in drug screening processes to identify potential therapeutic agents Experimental concentrations typically depend on the specific research design making it a versatile option for a wide array of scientific inquiries
Aobchem Triphenylene-2-carboxylic acid | ≥97% | CAS 109534-58-9 | C19H12O2 | 1g
Triphenylene-2-carboxylic acid | ≥97% | CAS 109534-58-9 | C19H12O2 | 1g
Medchemexpress LLC 2H-1-benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-(3R,4S) | 1213777-80-0 | 99.9% | 348.39 g/mol | C22H20O4 | 5 MG
Triphen diol is a phenol diol small-molecule research compound (CAS 1213777-80-0) reported to induce apoptosis and inhibit proliferation in pancreatic cancer models. It has molecular formula C22H20O4, molecular weight 348.39 g/mol, and is supplied with high reported purity for use in in vitro and in vivo studies. Solubility and storage guidance is provided to support experimental workflows.
- Phenol diol small-molecule with reported anticancer activity.
- Demonstrated apoptosis induction and antiproliferative effects in pancreatic cancer cell lines.
- High reported purity suitable for biological assays.
- Soluble in DMSO at concentrations useful for stock preparations.
- Reported in vivo formulation options that yield clear solutions at ≥2.5 mg/mL.
- Storage recommendations provided to maintain stability during short- and long-term storage.
eMolecules 141-82-2 | Malonic acid | Key Organics/BIONET104.061 | C3H4O4 | 95.000 | OC(=O)CC(O)=O | 10mg | 564178359
Malonic acid | Key Organics/BIONET | 141-82-2104.061 | C3H4O4 | 95.000 | OC(=O)CC(O)=O | 10mg | 564178359
Medchemexpress LLC Crizotinib hydrochloride | 1415560-69-8 | 99.7% | C21H23Cl3FN5O | 200 MG
Crizotinib hydrochloride is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor. It also acts as a ROS proto-oncogene 1 (ROS1) inhibitor, demonstrating effective tumor growth inhibition.
- Inhibits tyrosine phosphorylation of NPM-ALK and c-Met in cell-based assays
- Potently prevents cell proliferation by inducing G(1)-S-phase cell cycle arrest and apoptosis
- Causes marked regression of large established tumors in preclinical models
- Demonstrates a significant dose-dependent reduction of CD31-positive endothelial cells
- Leads to marked inhibition of phosphorylated c-Met, Akt, Erk, PLCλ1, and STAT5 levels
eMolecules 141-82-2 | Malonic acid | Oakwood Chemical104.061 | C3H4O4 | 99.000 | OC(=O)CC(O)=O | 1kg | 537678614
Malonic acid | Oakwood Chemical | 141-82-2104.061 | C3H4O4 | 99.000 | OC(=O)CC(O)=O | 1kg | 537678614